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As skin quality improves, the overall appearance of tone and texture may also benefit

Experimental and clinical studies identify FGF21 as a critical modulator of lipid oxidation, insulin sensitivity, and inflammatory balance, processes central to the pathogenesis of metabolic dysfunction-associated steatohepatitis (MASH)

(2018) 14:39040310.1038/s41574-018-0016-2 28

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A 2021 clinical trial published in The New England Journal of Medicine the STEP 1 trial showed that participants on semaglutide lost an average of 14.9% of body weight, but research on the body composition breakdown of that loss suggests a meaningful proportion can come from lean mass rather than fat, particularly when protein intake is inadequate