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As with other GLP-1 medications, orforglipron is not recommended for people with a personal or family history of thyroid tumors or multiple endocrine neoplasia type 2 (MEN2)

GLP-1 drugs seem to inhibit cravings for several different substances in multiple animal models

Yet, phase 3 trials of retatrutide are still ongoing and their results are yet to be released

Research Use Only: Important: This product is sold for research purposes only

They are not strictly necessary for subcutaneous self-injection, but they reduce the chance of introducing bacteria during reconstitution

They draw water into the bowel, softening stools and increasing frequency Bulk-forming laxatives (ispaghula husk, methylcellulose) work similarly to dietary fibre and are generally suitable for long-term use, but should be avoided if you have severe bloating or suspected impaction Stimulant laxatives (senna, bisacodyl) should be reserved for short-term use when other measures fail Rectal treatments (glycerol suppositories, small-volume enemas) can provide rapid relief for occasional constipation Establishing a regular toilet routine can be beneficial