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Sirtuin 1 and autophagy attenuate cisplatin-induced hair cell death in the mouse cochlea and zebrafish lateral line

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This smaller opening of the intracellular pocket for G protein is not suitable to engage with the G s protein due to potential steric hindrance (Supplementary Fig

Intriguingly, this effect required continuous exposure to APAP, as animals fed APAP overnight (to simulate a brief/singular dose) showed a mild reduction in survival, but the reduction in survival was not as significant as those who experienced continuous exposure (Supplemental Fig

These findings suggest that the additional GIP receptor agonism provides clinical benefits beyond GLP-1 activation alone