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In in vitro experiments, GLP-1RAs have been shown to bind to GLP-1R on endothelial cells, leading to activated eNOS, increased NO production, and inhibition of NF-B activation, thereby protecting endothelial cells (Tang et al., 2018

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Proteinuria was also reported in 5% of treated patients and is hypothesized to be a result of gold or gold complexes from auranofin damaging the renal tubule

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