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Differences between controlled trial settings and broader real-world populations affect outcomes

Additionally, murine collagen-induced arthritis (CIA) is a T celldependent, antibody-mediated autoimmune disease that is directed against cartilage type II collagen (CII) 19

These effects are separate from genetic recombination effects and are an important confounding variable in experimental designs that rely on comparisons to a vehicle-treated control

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Additionally, obstructive sleep apnoea affects over half of people with type 2 diabetes and its severity is associated with blood glucose levels [115, 116]

doi: 10.1096/fj.00-0893fje