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In patients with type 2 diabetes, semaglutide is reported to improve glycaemic control dose-dependently, decreasing HbA 1c levels by 1.7% (18.7 mmol/mol) vs 0.5% (5.5 mmol/mol) with placebo and 4.8 kg of weight loss vs 1.2 kg with placebo, relative to baseline

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These are similar in magnitude, albeit slightly improved, to the reductions observed for the efficacy estimand for tirzepatide 10 and 15 mg versus semaglutide 2.4 mg in this NMA (mean [95% CrI] weight reduction 3.78% [ 6.99, 3.66], 4.86 [ 8.07, 2.67]

Estimating the annual cost burden of diabetic peripheral neuropathy in the United States

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