tirzepatide 0.5 GIP also stimulates insulin production and release from the pancreas Tirzepatide 5mg

doi: 10.1016/S1474-4422(24)00430-7 [PubMed] 41260851 Siegel CR, Khoujah D

Lean mass does include more than just skeletal muscle, but preserving muscle is essential, particularly in midlife and older adults, where age-related muscle loss (sarcopenia) is already occurring

Journal of Clinical Endocrinology & Metabolism, 100 (2), 342362

Theres no head-to-head trial of retatrutide against Mounjaro or Wegovy, and none has been announced

Direct lactylation is also regulated by specific enzymes, so enzyme activity plays a key role in this modification (Moreno-Yruela et al., 2022)

The fact that OCN IGF-IR KO mice failed to respond to GH treatment to increase bone mass suggests that IGF-IR-dependent actions of GH are the predominant responses to promote skeletal anabolism (70)