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Clinical evidence shows an average weight loss of 15 to 20 percent over 72 weeks, meaning for someone weighing 250 pounds, this could translate to a 37 to 50-pound weight reduction

Marx N, Libby P

People with type 2 diabetes were excluded

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Summary: Allergy medication and propranolol can interact in clinically significant ways, most critically by reducing the effectiveness of adrenaline during anaphylaxis and causing dangerous blood pressure rises with sympathomimetic decongestants