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This creates a feed-forward loop wherein ferroptotic cells, laden with oxidized lipids, serve as transcellular donors of AA and oxidized AA derivatives, fueling inflammatory lipid mediator production in neighboring cells

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A catalytic site mutant 3MST C247S, which has lost the activity to produce H 2 S and H 2 S n , did not decrease cysteine levels (Fig

Ferroptosis: molecular mechanisms and health implications

We showed that MeCbl downregulated the activity of Erk1/2 and promoted the expression of the myelin basic protein in SCs