Cisplatin-resistant OSCC cells suppress ferroptosis through upregulation of the SLC7A11-GSH-GPX4 axis, while reactivating ferroptosis can restore cisplatin sensitivity and reverse the resistant phenotype ( inhibitor erastin promotes ferroptosis via a ROS-dependent mechanism, enhances cisplatin cytotoxicity in OSCC cells, and exhibits no overt toxicity in vivo , providing a clinically translatable approach to overcome cisplatin resistance
10.1016/j.heliyon.2023.e15613 73 MorganM
[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Pickart L
Bpc-157 Is A Synthetic Peptide That Has Been Studied Mainly In Laboratory And Animal Research
GHK-Cu has the deepest foundation among these over 100 published studies across five decades
Pineal, melatonin, and rhythms of light and dark Carrying the pineal signature of Epithalon, the remedy works strongly on rhythms of light and dark, day and night, activity and rest