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Histone methylation could either activate gene transcription (H3K4, H3K36, and H3K79) or silence gene expression (H3K9 and H3K27), which depends on the modification site

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The control group (CON group) and the CON + H8 group received tail vein injections of blank plasmid, while the 11-HSD1 group and the 11-HSD1 + H8 group were injected with 11-HSD1 lentivirus via the tail vein

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Girn-Arango L, Perlas A