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DiCostanza (Clinical Operations at MedImmune LLC, Gaithersburg, MD, USA) for study management and T

In summary, different GLP-1RAs improve skeletal muscle atrophy through multiple molecular mechanisms, involving multiple pathways such as insulin resistance regulation, inflammation suppression, and mitochondrial function improvement (see Table 1), providing a theoretical basis for the clinical treatment of sarcopenia with GLP-1RAs

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Participation of cathepsin L on bone resorption

TUNEL assay On experimental day P38, pancreas samples were fixed in 2% w/v paraformaldehyde for 2 h and processed for TUNEL assay, which was performed using the One Step TUNEL Apoptosis Assay Kit (Beyotime, Shanghai, China) according to the manufacturers instructions