In preclinical work it up- and down-regulates a large number of genes tied to matrix production, remodeling, and antioxidant defense, and it ferries copper a cofactor for lysyl oxidase and superoxide dismutase into tissue
When administered into the brain circulation and cerebrospinal fluid of mice, DSIP showed a significant, dose-dependent reduction in pain response in the tail-pinch and hot-plate tests
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doi: 10.52965/001c.125267