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doi: 10.1073/pnas.042707999 75 EmanueleS.CelesiaA.DAnneoA.LauricellaM.CarlisiD.De BlasioA.et al

These elevated levels seemed sufficient to evaluate the consequences on the cell

Instead, the researchers found that one of its metabolic breakdown productsthe smaller fragment Ac-LKKTEwas responsible for the biological activity, suggesting that the entire pharmacological understanding of how TB-500 operates may be flawed or incomplete

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