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Notably, the present narrative review is an extension of a previous review article that covered polyphenols and/or phytoestrogens that included daidzein, equol, genistein, and resveratrol as supplemental therapies for skin aging, which was published in Dermatology and Therapy earlier this year by Lephart (2025) [9]

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The agency cited safety risks including potential carcinogenicity, immunogenicity, and concerns about impurities and noted that most of these substances had never undergone rigorous human clinical trials

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This model can lead to increased enrollment and retention by meeting participants where they are, both physically and logistically