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DECLARATIONS Authors contributions Controlled the study design and preparation of the article: Ciancimino G, Pecorella F, Viscardi SM, La Mantia C, Caserta A, Pennisi G, Petta S Participated in planning and drafting the article: Ciancimino G, Pecorella F, Viscardi SM, La Mantia C, Caserta A, Pennisi G, Petta S Approved the final draft of the article: Ciancimino G, Pecorella F, Viscardi SM, La Mantia C, Caserta A, Pennisi G, Petta S Availability of data and materials Not applicable

It is only synthesized by bacteria, so it must be consumed by humans through dietary sources such as animal products, cheese, and milk

Keywords: oral health, oral medicine, oral pathology, pigmented lesions, malignant melanoma, oral pigmentation, melanin, mouth mucosa 1

Other stress reduction techniques that may be helpful include: yoga, meditation, and deep breathing [7]