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the fastest growth in metabolic disease prevalence is occurring in low- and middle-income countries across Southeast Asia, Sub-Saharan Africa, Latin America, and the Middle East, regions where rising caloric intake, reduced physical activity, and rapid urbanization are converging to create massive unmet therapeutic needs

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Among them, 4-HNE-modified proteins [39] and MDA-modified proteins [40] are the most commonly studied

Small tweaks to the molecular structures allow the medications to avoid breakdown and exert their effects for longer periods of time

Early recognition and treatment of these deficiencies can help prevent and manage various neuropsychiatric conditions, thereby enhancing overall mental health (6)