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Primary human research route: Intranasal drops or measured intranasal solution

The within-individual variation from dose to dose in oral semaglutide bioavailability was relatively high, but as a result of daily dosing and a long plasma half-life (1 week), the variability of semaglutide exposure at steady state was considerably reduced

Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, et al

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Its profile has supported research into coordinated endocrine signaling, metabolic adaptation, weight-related biology, glucose regulation, and energy expenditure

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