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American Journal of Clinical Nutrition, 115 (3), 608-618

One notable behavioral reaction: a small number of participants were reportedly reluctant to continue the study because the weight loss felt too extreme, though such reports are anecdotal and not a formal safety signal

Aggregated, gastrointestinal adverse reactions occurred in 32.7% of patients on 0.5 mg and 36.4% on 1 mg versus 15.3% on placebo

Collagen supplementation supports connective tissue alongside muscle protein

Some researchers find that starting at even lower doses than the clinical trial protocols and escalating more slowly can reduce the severity of gastrointestinal symptoms

Nature 619 , 143150 (2023)