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SGLT2 inhibitors (such as dapagliflozin): Reduces cardiovascular risk

Only 28.8% of participants exceeded 1 mg/week

Clinical trial protocols started at 1mg weekly with gradual escalation

This brief duration of action is why pharmaceutical companies developed longer-acting GLP-1 receptor agonists for therapeutic use

Compounded retatrutide is a separate category and the FDA has issued public statements warning about online sellers using research-use labels

Conclusions and Relevance This randomized clinical trial found that continuing GLP-1 or GIP agonist in the preprocedural period increased clinically significant RGV but did not increase the risk of other adverse events