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Oral users see more variation between doses because the within-subject variability in bioavailability is roughly 137% for individual doses

Incidence of depression and associated factors in patients with type 2 diabetes in Quebec, Canada: a population-based cohort study

This means they have been evaluated for safety and efficacy in clinical trials

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A trial evaluating 60 patients with MCI or probable AD discovered that treatment with 40 IU of the long-acting insulin analog, insulin detemir, improved cognition [162]

So watch out for potential adverse reactions like stomach problems, difficulty breathing, skin irritations, or thyroid tweaks