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Wegovy: Package Insert / Prescribing Info Package insert / product label Generic name: semaglutide Dosage forms: injection, solution, oral tablet Drug class: GLP-1 Drugs Medically reviewed by Drugs.com

Abbreviations: AUD Alcohol Use Disorder CVD Cardiovascular Disease DALYS Drug-related Disability-Adjusted Life Years eGFR Estimated Glomerular Filtration Rate GIP Gastric Inhibitory Polypeptide GLP-1RA Glucagon-like peptide 1 agonists HF Heart Failure HFpEF Heart Failure with Preserved Ejection Fraction T2D Type 2 Diabetes MACE Major Adverse Cardiovascular Events MASLD Metabolic Dysfunction-Associated Steatotic Liver Disease MI Myocardial Infarction NAc Nucleus Accumbens OSA Obstructive Sleep Apnea PCOS Polycystic Ovarian Syndrome RCT Randomized Placebo-controlled Trials UACR Albumin-to-Creatinine Ratio US United States VTA Ventral Tegmental Area Footnotes Disclosures/COI: JHO Speaker bureau for Amgen, Boehringer, and Lilly WFG no disclosures ELO - The National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number T32HL110837 supported the research reported in this publication

Vascular endothelial growth factor (VEGF) and its receptors, as key factors promoting angiogenesis, are upregulated under hypoxic conditions