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(2018) Differential efficacy of methylcobalamin and alpha-lipoic acid treatment on symptoms of diabetic peripheral neuropathy
In the present study, an increased abundance of enzymes involved in fatty acid catabolism was observed, including long-chain acyl-CoA synthetase (log 2 FC = 1.04), peroxisomal multifunctional enzyme type 2 (log 2 FC = 0.79), hydroxy methylglutaryl CoA-lyase (log 2 FC = 0.84), 3-ketoacyl-CoA-thiolase-A (log 2 FC = 1.39)
325,326 This improvement is achieved through the inhibition of ferroptosis by downregulating ACSL4 expression via a PPAR--independent pathway
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The more muscle you have, the better your metabolism and fat-burning capabilities