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Lactic acid bacteria contribution to gut microbiota complexity: lights and shadows

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They were one of my original bullish write-ups as a clinical-stage biotech company

doi: 10.1016/j.aller.2013.03.004

Notably, the majority of mechanistic data supporting this concentration-dependent model derives from preclinical studies using mouse pancreatic -cells and clonal cell lines, with limited validation in human islet studies, necessitating further clinical investigation to confirm these concentration thresholds in human diabetes treatment [23,24,25,26]

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Yang Y., Hu X., Xiong L., Fu P., Feng W., Li W., Zhang L., Sun F