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DOI:10.2147/hmer.S546357 61

However, native GLP-1 has a limited half-life (1.55 min) due to its degradation by the enzyme Dipeptidyl peptidase 4 (DPP-4), necessitating the development of GLP-1 receptor agonists (GLP-1RAs) with longer activity (Campbell and Drucker 2013)

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BPC-157: 0.25-0.5 mg daily subcutaneous TB-500: Loading phase 2.5 mg twice weekly for weeks 1-4, then maintenance 2-3 mg weekly Duration: 6-8 weeks concurrent use Note: Administer separately

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BMS-754807 is a potent IGF-1R inhibitor, which has been reported to have a limited off-target effect since the transcriptional profile is similar between wild-type MEF cells treated with BMS-754807 and IGF-1R null MEF cells