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The 28-day rule United States Pharmacopeia (USP) general guidelines indicate multi-dose vials containing preservatives such as benzyl alcohol may be used for up to 28 days after the initial puncture, provided they are stored properly and free from visible contamination

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The Mayo Clinic notes that even at therapeutic mega-doses, side effects are uncommon and mild: headache, nausea, diarrhea, fatigue, and a tingling sensation in extremities

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Taking vitamins and supplements is a good insurance policy to fill in any dietary gaps