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Specifically, rutin can significantly upregulate the expression of ferritin heavy chain (FTH) and glutathione peroxidase 4 (GPX4), and downregulate the expression of acylCoA synthetase long-chain family member 4 (ACSL4), thereby inhibiting iron-dependent lipid peroxidation

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Proceedings of the National Academy of Sciences 103 , 1160711612 (2006)