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The problem with inexpensive glutathione supplements is that GSH is inherently unstable: the thiol group of the molecule oxidises relatively quickly to the inactive GSSG form upon exposure to heat, light or oxygen

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doi:10.1186/s13195-024-01666-7

Importantly, obesity-driven chronic systemic inflammation is a key setting in which tryptophan-kynurenine (TRP-KYN) pathway metabolites are believed to play a mechanistic role, contributing to the development of obesity-related comorbidities including T2DM (Yeung et al., 2022)

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