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4), explaining the observed stabilisation of the D-antigenic state by GSH

LC separation, which followed the previously reported procedure 28 , was performed using a normal-phase (hydrophilic interaction chromatography, HILIC) column (ZIC-pHILIC

The approval matters because it validates a long-sought oral small-molecule route to GLP-1 agonism, with potentially major consequences for convenience, manufacturing scale, pricing, and patent strategy