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321 Ligandreceptor binding results in the release of the Notch intracellular domain (NICD) and NICD interaction with recombination signal-binding protein immunoglobulin kappa J (RBPJ) to initiate the transcription of downstream target genes such as HES/HEY

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Financial support and sponsorship This work was supported by NIH grant R01 AG057381, Ladiges, PI

By healing the gut lining and decreasing inflammation, the peptide provides a protective layer against drug-induced damage, thus improving the bodys resilience to the negative effects of some pharmaceuticals

Temperature matters significantly