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The demographic distribution of those most likely to stop treatment was as follows: patients of color, men, people enrolled in Medicare or Medicaid, those living in areas with very high social needs, heart failure, obesity or other cardiovascular diseases prior to drug initiation, and those experiencing new gastrointestinal adverse effects at follow-up [132]

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Realistic Timeframes: The company notes several weeks of consistent use as typical before changes may be noticed, if any occur

Topiramate has similar benefits for weight reduction in psychiatric patients, but cognitive impairment limits its usage (McIntyre RS et al, Am J Psychiatry 2024;181(1):2638)