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Chemical modifications such as lipidation (first applied therapeutically to insulin in the 1990s), PEGylation (established as a platform technology in the early 2000s), and reversible albumin binding have transformed peptides from short-lived signaling molecules into durable therapeutics suitable for weekly or even monthly administration (Langer, 1998

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Read PA, Khan FZ, Dutka DP

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Sustained intakes below ~1,200 kcal/day in women and ~1,5001,800 kcal/day in men jeopardize not only muscle mass, but also endocrine, neurologic, and micronutrient homeostasis