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The first patient, treated in 1906, was a 50 year old dying man who had just had his toe amputated due to gangrene from diabetes and was in a diabetic coma

Because these reactions are reported voluntarily from a population of uncertain size, it is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure

(The FDA has received more than 700 adverse event reports tied to compounded GLP-1s, but its not clear if the events were caused by the drugs.) The companies also see compounders as a threat to their obesity drug sales, which are estimated to balloon to $100 billion a year by 2030

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Under the Dietary Supplement Health and Education Act (DSHEA), these products are regulated as foods, not medications, and manufacturers cannot legally claim they treat, cure, or prevent disease