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Our study revealed that the level of MDA was significantly elevated in the liver of HFD-fed rats compared to animals fed a standard diet which indicates lipid peroxidation and suggests that HFD induces oxidative stress in hepatocytes

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The trial showed: Tirzepatide 5 mg: 7.6 kg weight loss Tirzepatide 10 mg: 9.3 kg weight loss Tirzepatide 15 mg: 11.2 kg weight loss Semaglutide 1 mg: 5.7 kg weight loss Some articles looked at those numbers and decided "tirzepatide 10 mg is roughly equivalent to semaglutide 1 mg" because 9.3 kg is about 1.6x more than 5.7 kg, and 10 mg is 10x more than 1 mg, so the "potency ratio" is around 6:1

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The fluid retention can also increase blood pressure and stress the cardiovascular system

Management is supportive, with a focus on fluid resuscitation and antiemetic therapy