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The presence of 6 or more CALMs (measuring 0.5 cm in prepubertal children and 1.5 cm in adults) represents a criterion for the diagnosis of neurofibromatosis type 1 (NF1) that is met by most affected individuals by adolescence (Chapter 360)

Castrn [email protected] This article was submitted to Psychopharmacology, a section of the journal Frontiers in Psychiatry Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Understanding the mechanism, safety profile, and monitoring requirements of this combination is essential before starting treatment