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We have appraised treatment efficacy in the 33 trials with histological outcome measures (Supplementary Table 1, trials labeled in red) from seven perspectives, i.e

Retatrutide is one of the most promising new weight-loss and metabolic health drugs currently in clinical development

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Clinical trials suggest that patients who achieve at least 5% body weight loss by months three to four are likely to be long-term responders

Conducting long-term studies to evaluate the sustained effects of GLP-1 agonists and bariatric surgery on weight loss, glycemic control, and other outcomes is crucial for understanding their long-term benefits and risks