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Sildenafil is a phosphodiesterase type 5 ( PDE5 ) inhibitor, which breaks down cyclic GMP and enhances nitric oxide (NO) -mediated smooth muscle relaxation

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It does not act directly on free radicals but is a vital part of most antioxidant enzymes (metalloenzymes, glutathione peroxidase, and thioredoxin reductase) that would have no effect without it [47]

Nature 554, 128132

Why Hospira Pfizer

patients with severe gastrointestinal disease or gastroparesis may not be suitable candidates Hypersensitivity reactions : Including anaphylaxis, have been reported rarely Injection site reactions , including erythema, pruritus, or induration, occur in approximately 25% of patients and are generally self-limited