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Camptothecin (CPT) and its derivatives are known to target topoisomerase I (Top1) as their mechanism of action: did we miss something in CPT analogue molecular targets for treating human disease such as cancer

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Research protocols investigating long-term melanocortin signaling typically employ pulsatile dosing schedules (e.g., 1mg every 4872 hours instead of daily) to allow receptor resensitization between administrations

30 Tretinoin alone, even without benzoyl peroxide, can degrade 60-80% when exposed to normal daylight over a period of 24 hours

Williams JT, et al