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The human genome encodes up to 17 genes of cytosolic (soluble) GSTs, but two of them are frequently represented by null alleles, GSTM1*0 and GSTT1*0 , such that the affected individuals do not express the corresponding enzymes 9

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Biomolecules, 5 (2), 356

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Rising levels of NAPQI in the liver cause widespread damage, including lipid peroxidation, inactivation of cellular proteins, and disruption of DNA metabolism (Bessems 2001)