Along the way, youll hear about the biology of the GLP-1 molecule and its related peptides, learn more about how GLP-1 agonists promote glycemic control, weight loss, and cardiometabolic health, and explore the current body of literature supporting the individualized application of these medications to patients with diabetes, obesity, and/or ASCVD
If youre beginning treatment, hitting a plateau, or considering stopping, youll find practical guidance here
demonstrated that GLP-1 treatment decreased phosphorylation of extracellular signal-regulated kinases ERK1/2 and additionally reversed downregulation of epigenetic factor histone deacetylase 6, a downstream molecular of the EKR1/2 whereby significantly reduced intracellular reactive oxygen species [128]
GLP-1, a marker of early intestinal mucosal injury, was significantly increased after LPS injection in a mouse model of intestinal injury induced by lipopolysaccharide (IPOLPS) (Lebrun et al., 2017)
Mitochondrial Respiration and Hypoxia Protection The 2003 study by Khvatova, Samartzev, Zagoskin, Prudchenko, and Mikhaleva published in Peptides confirmed that DSIP significantly increased ADP-stimulated mitochondrial respiration in rat brain mitochondria under experimental hypoxia conditions establishing a direct mitochondrial respiratory mechanism for DSIPs stress-protective potency and linking DSIP biology to the emerging field of mitochondria-targeted neuroprotective peptides
Jan 1 2018;24(1):86-105
