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Although regulating the MUFA/PUFA ratio by lactate through the SCD1/ASCL4 pathway does affect membrane lipid peroxidation sensitivity, this protective effect against ferroptosis may be more highly dependent on the state of the intracellular antioxidant system (83)

In addition to thrombosis in larger vessels, microthrombi can also play an important role in CV pathology, but the mechanism behind SARS-CoV-2-associated coagulopathy is not well understood (20)

2020;219 doi: 10.1016/j.clim.2020.108544