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In Model 2, higher ProBDNF levels were associated with cocaine use (a = 23.59, 95% CI: 3.6943.49, p = 0.023), psychopharmaceutical intake (a = 42.71, 95% CI: 19.9565.46, p = 0.001), and previous psychiatric hospitalization (a = 60.64, 95% CI: 27.0194.26, p = 0.001), whereas a previous psychiatric diagnosis was negatively associated with the outcome (a = 43.43, 95% CI: 66.76 to 20.10, p = 0.001)

GLP-1 medicationssuch as compounded tirzepatide and semaglutide or branded Zepbound, Mounjaro, Wegovy, and Ozempic are transforming the way we approach weight loss, metabolic health, and long-term disease prevention

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These findings highlight the potential of tirzepatide to address both metabolic risk factors and alcohol intake in patients with alcohol-associated liver disease