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"Weight regain after stopping treatment may affect the long-term sustainability of the observed benefits

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Major clinical trials show the most significant changes occur over 6-12+ months when combined with healthy habits

Some studies indicate that GLP-1 RAs may help reduce the frequency of arrhythmias due to their beneficial impact on metabolic parameters and overall cardiovascular health ( One of the main causes of the excess cardiovascular risk in diabetics is the coexistence of hypertension

Obesity and weight retention involve complex metabolic and hormonal factors far beyond simple calories in versus calories out

PMID 8405712