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10.3233/JAD-111982 [DOI] [PubMed] [Google Scholar] Fabiani C, Murray AP, Corradi J, Antollini SS (2018) A novel pharmacological activity of caffeine in the cholinergic system

For instance, two siblings both harboring the same mitochondrial mutation causing Lebers hereditary optic neuropathy had markedly different clinical courses: the brother exhibited typical progressive optic neuropathy whereas the sister suffered from a relapsingremitting MS-like illness (Joshi and Kermode, 2019)