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Current leading GLP1 receptor agonist peptides were developed for prolonged pharmacokinetics compatible with onceweekly administration in humans

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7.3 Overarching challenges and future directions Future research priorities include clarifying the context-dependent duality of IGF-1, delineating its protective versus pathogenic roles across disease stages and cell types, and mapping crosstalk with core PAH pathways such as BMPR2/TGF- signaling

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