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These same receptors exist in reproductive tissues, which is why fertility specialists recommend discontinuing the medication before conception

The 12-week standard escalation gives each receptor system adequate time to adjust

Because of this, certain foods can contribute more to the GI side effects, like spicy and high-fat foods

The FDA Zepbound label reports hair loss more often in women than men, 7.1% vs 0.5%, and explicitly notes the reaction was associated with weight reduction in trial participants

Seek immediate medical attention for: Severe, persistent abdominal pain, especially if different from typical IBS pain or radiating to the back (possible pancreatitis) Persistent vomiting preventing adequate fluid intake Signs of dehydration (decreased urination, dizziness, extreme thirst) Severe constipation lasting more than 3-4 days without bowel movement Blood in stool or black, tarry stools Yellowing of skin/eyes, right upper quadrant pain (possible gallbladder disease) Markedly reduced urination (possible acute kidney injury) Fever accompanying gastrointestinal symptoms Neck mass, difficulty swallowing, persistent hoarseness (thyroid concerns) Allergic reactions (rash, itching, swelling, severe dizziness) Scheduled follow-up should occur within 4-6 weeks of initiating therapy and after each dose escalation

It should be individualized based on tolerability