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The selective ULK1/2 inhibitor, DCC-3116, synergizes with the KRASG12C inhibitor sotorasib to suppress KRAS-driven LC, whereas this combination has been assessed only in early preclinical stages and lacks predictive biomarkers for patient stratification (17)

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Matsumine A, Kusuzaki K, Nakamura T, Nakazora S, Niimi R, Matsubara T, et al