tirzepatide chemical structure | C225H348N48O68 | CID 156588324 Antidiabetic drug tirzepatide molecula |

[DOI] [PubMed] [Google Scholar] Bonomini M., Di Liberato L., Zammit V., Arduini A

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In the kidney, dual GLP-1R/GIPR stimulation attenuates MCP-1, IL-6, and tumor necrosis factor (TNF)- expression and down-regulates SGLT2 messenger ribonucleic acid (mRNA), potentially reinforcing natriuresis and glycosuria when GLP-1RA are combined with SGLT2 inhibitors [26]

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Retatrutide is investigational and not yet FDA-approved

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