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It does not slot neatly into an endocrine signaling cascade

Sensitization, glutamate, and the link between migraine and fibromyalgia

Bergmann et al

doi: 10.1211/0022357011777747 65 ZhaoDYuYZhaoZSharmaRReiterRJ

Cell Death Dis 8 , e2848 (2017)

A peer-reviewed overview in the International Journal of Molecular Sciences (Araj et al., Medical University of Warsaw, 2025) establishing Epithalon as a highly bioactive pineal tetrapeptide with documented mechanisms spanning telomere maintenance, epigenetic regulation, antioxidant defense, immune recalibration, and circadian rhythm restoration provides the scientific framework for all five mechanisms described in this section