While our trial focused on cardiovascular events, many other chronic diseases including several types of cancer, osteoarthritis, and anxiety and depression would benefit from effective weight management. John Deanfield, a professor of cardiology at University College London who led the companion study, added that the findings suggest that semaglutide has other actions which lower cardiovascular risk beyond reducing unhealthy body fat. These alternative mechanisms may include positive impacts on blood sugar, blood pressure, or inflammation, as well as direct effects on the heart muscle and blood vessels, or a combination of one or more of these, he said
It experimentally induced inflammatory reactions in the rat with the interference of eicosanoid formation in the arachidonic acid cascade (124) and could modulate the immune system as an anti-inflammatory factor (71)
We compared the prevalence of NCHPTH in our MBDS to other referral populations, finding an increased prevalence in our service, likely due to the high frequency of skeletal compromise in this population
For any mental health changes, consult your physician before stopping medication
GLP-1 receptor agonists are meant to be taken long-term, but that will look different for each individual
These are predominantly related to gastrointestinal tract, namely nausea, diarrhea, and vomiting as well as constipation and gastroparesis [122], while there is also some evidence of gallbladder-associated adverse effects due to rapid loss of body weight [122,123]
